Key background papers from the team

Burslem, G.M., et al. (2017) Hypoxia inducible factor (HIF) as a model for studying inhibition of protein-protein interactions. Chem. Sci. 8, 4188-4202.

Grison, C.M., et al. (2017) Double quick, double click reversible peptide “stapling”. Chem. Sci. 7, 5166,-5171.

Miles, J.A., et al. (2016) Hydrocarbon constrained peptides – understanding preorganisation and binding affinity. Chem. Sci. 7, 3694-3702.

Azzarito, V., et al. (2015) Stereocontrolled protein surface recognition using chiral oligoamide proteomimetic foldamers. Chem. Sci. 6, 2434-2443.

Baker, E.G., et al. (2015) Local and macroscopic electrostatic interactions in single α-helices. Nat. Chem. Biol. 11, 221-228.

Barnard, A., et al. (2015) Selective and Potent Proteomimetic Inhibitors of Intracellular Protein–Protein Interactions. Angew. Chem. Int. Ed. 54, 2960-2965.

Doveston, R.G., et al. (2015) A unified lead-oriented synthesis of over fifty molecular scaffolds. Org. Biomol. Chem. 13, 859-865.

Foley, D.J., et al. (2015) A systematic approach to diverse, lead-like scaffolds from [small alpha],[small alpha]-disubstituted amino acids. ChemComm. 51, 11174-11177.

Karageorgis, G., et al. (2015) Activity-Directed Synthesis with Intermolecular Reactions: Development of a Fragment into a Range of Androgen Receptor Agonists. Angew. Chem. Int. Ed. 54, 13538-13544.

Karawajczyk, A., et al. (2015) Expansion of chemical space for collaborative lead generation and drug discovery: the European Lead Factory Perspective. Drug Discovery Today, 20, 1310-1316.

McIntosh-Smith, S., et al. (2015) High performance in silico virtual drug screening on many-core processors. Int. J. High Perform. Comput. Appl. 29, 119-134.

Burslem, G.M., et al. (2014) Small-Molecule Proteomimetic Inhibitors of the HIF-1α–p300 Protein–Protein Interaction. ChemBioChem. 15, 1083-1087.

Karageorgis, G., S. Warriner, and A. Nelson (2014) Efficient discovery of bioactive scaffolds by activity-directed synthesis. Nat.Chem. 6, 872-876.

Thomson, A.R., et al. (2014) Computational design of water-soluble α-helical barrels. Science 346, 485-488.

Wood, C.W., et al. (2014) CCBuilder: an interactive web-based tool for building, designing and assessing coiled-coil protein assemblies. Bioinformatics 30,  3029-3035.

Azzarito, V., et al. (2013) Inhibition of [alpha]-helix-mediated protein-protein interactions using designed molecules. Nat, Chem. 5, 161-173.

Bartlett, G.J., et al. (2013) Interplay of Hydrogen Bonds and n→π* Interactions in Proteins. JACS 135, 18682-18688.

Fletcher, J.M., et al. (2013) Self-Assembling Cages from Coiled-Coil Peptide Modules.  Science 340, 595-599.

Fletcher, J.M., et al. (2012) A Basis Set of de Novo Coiled-Coil Peptide Oligomers for Rational Protein Design and Synthetic Biology.  ACS Synth. Biol, 1, 240-250.

McIntosh-Smith, S., et al. (2012) Benchmarking Energy Efficiency, Power Costs and Carbon Emissions on Heterogeneous Systems. Comput. J. 55, 192-205.

Bartlett, G.J., et al. (2010) n→π* interactions in proteins. Nat. Chem. Biol. 6,  615-620.