PoPPI Outputs

The following is a list of papers published as part of the programme

Zhang, P., Walko, M., Wilson, A.J., (2023) Maleimide constrained BAD BH3 domain peptides as BCL-xL Inhibitors: A Versatile Approach to Rapidly Identify Sites Compatible with Peptide Constraining. Bioorg. Med. Chem. Lett., 87, 129260.

Srdanovic, S., Hegedus, Z., Warriner, S.L., & Wilson, A.J. (2022) Towards Identification of Protein-Protein Interaction Stabilizers via Inhibitory Peptide-Fragment Hybrids Using Templated Fragment Ligation, Chem. Biol., DOI: 10.1039/D2CB00025C.

Hobor, F., Hegedus, Z., Ibarra, A.A., Petrovicz, V.L., Bartlett, G.J., Sessions, R.B., Wilson, A.J. & Edwards, T.A (2022) Understanding p300-transcription factor interactions using sequence variation and hybridization RSC Chem. Biol., DOI: 10.1039/D2CB00026A

Srdanovic, S., Wolter, M., Trinh, C.H., Ottmann, C., Warriner, S.L. & Wilson, A.J (2022) Understanding the interaction of 14-3-3 proteins with hDMX and hDM2: a structural and biophysical study FEBS J, DOI:10.1111/febs.16433.

Batchelor, M., Dawber, R.S., Wilson, A.J. & Bayliss, R (2021) α-Helix stabilization by co-operative side chain charge-reinforced interactions to phosphoserine in a basic kinase-substrate motif Biochem J., 479, 687-700.

Hetherington, K., Dutt, S., Ibarra, A.A., Cawood, E.E., Hobor, F., Woolfson, D.N., Edwards, T.A., Nelson, A., Sessions, R.B. & Wilson, A.J. (2021) Towards optimizing peptide-based inhibitors of protein–protein interactions: predictive saturation variation scanning (PreSaVS) RSC Chem. Biol. 2, 1474-1478.

Wang, H., Dawber, R., Zhang, P., Walko, M., Wilson, A.J. & Wang, X. (2021) Peptide-Based Inhibitors of Protein-Protein Interactions: Biophysical, Structural and Cellular Consequences of Introducing a Constraint, Chem. Sci., Chem. Sci.,12, 5977-5993.

Ueda, T., Tamura, T., Kawano, M., Shiono, K., Hobor, F., Wilson, A.J. & Hamachi, I. (2021) Enhanced Suppression of a Protein–Protein Interaction in Cells Using Small-Molecule Covalent Inhibitors Based on an N-Acyl-N-alkyl Sulfonamide Warhead J. Am. Chem. Soc. 143, 12, 4766–4774.

Celis, S., Hobor, F.,  James, T., Bartlett, G.J., Ibarra, A.A., Shoemark, D.K., Hegedus, Z., Hetherington, K., Woolfson, D.N., Sessions, R.B., Edwards, T.A. , Andrews, D.M.,  Nelson, A. & Wilson, A.J. (2021) Query-Guided Protein-Protein Interaction Inhibitor Discovery, Chem. Sci. 10.1039/d1sc00023c.

Hegedüs, Z., Hobor, F., Shoemark,  D.K., Lian, L.-Y., Trinh, C., Sessions, R.B., Edwards, T.A. & Wilson, A.J. (2021) Identification of β-Strand Mediated Protein-Protein Interaction Inhibitors Using Ligand-Directed Fragment Ligation, Chem. Sci., 12, 6, 2286-2293.

Cawood, E.E., Karamanos, T.K., Wilson, A.J. & Radford, S.E. (2021) Visualizing and trapping transient oligomers in amyloid assembly pathwaysBiophys. Chem., 268, 106505.

Cawood, E.E., Guthertz, N., Ebo, J., Karamanos, T., Radford, S.E. & Wilson, A.J. (2020) Modulation of Amyloidogenic Protein Self-Assembly Using Tethered Small Molecules, J. Am. Chem. Soc., 142, 49, 20845–20854.

Miles, J., Hobor, F., Trinh, C., Taylor, J., Tiede, C., Rowell, C., Jackson, B., Nadat, F., Ramsahye, P., Kyle, H., Wicky, B., Clarke, J., Tomlinson, D., Wilson, A.J., Edwards, T.A. (2020) Selective Affimers Recognize the BCL‐2 Family Proteins BCL‐xL and MCL‐1 through Non‐Canonical Structural Motifs, ChemBioChem, 22, 1, 232-240.

Wolter, M., de Vink, P., Neves, J.F., Srdanovic, S., Higuchi, Y.,  Kato, N., Wilson, A.J., Landrieu, I., Brunsveld, L., & Ottmann, C. (2020) Selectivity via Cooperativity: Preferential Stabilization of the p65/14-3-3 interaction with Semi-Synthetic Natural Products, J. Am. Chem. Soc., 142, 27, 11772–11783.

Green, A., Hobor, F., Tinworth, C., Warriner, S., Wilson, A.J., & Nelson, A. (2020) Activity‐directed synthesis of inhibitors of the p53/hDM2 protein‐protein interaction, Chem.Eur., 26, 47, 10682-10689.

Hetherington, K., Hegedus, Z., Edwards, T.A., Sessions, R.B., Nelson, A., Wilson, A.J. (2020) Stapled Peptides as HIF‐1α/p300 Inhibitors: Helicity Enhancement in the Bound State Increases Inhibitory Potency, Chem. Eur. J., 26, 34, 7638-7646.

Lindsey-Crosthwait, A., Rodriguez-Lema, D., Walko, M., Pask, C. and Wilson, A.J. (2020) Structural optimization of reversible dibromomaleimide peptide stapling, Peptide Science, 113, 1, e24157.

Wood, C.W., Ibarra, A.A., Bartlett, G.J., Wilson, A.J., Woolfson, D.N., Sessions, R.B. (2020) BAlaS: fast, interactive and accessible computational alanine-scanning using BudeAlaScan, Bioinformatics, 36, 9, 2917–2919.

Ibarra, A.,  Bartlett, G.J., Hegedus, Z., Dutt, S., Hobor, F.,  Horner, K., Hetherington, K., Spence, K., Nelson, A., Edwards, T.A., Woolfson, D.N., Sessions, R., Wilson, A.J. (2019) Predicting and Experimentally Validating Hot-Spot Residues at Protein-Protein Interfaces, ACS Chem. Biol., 14, 10, 2252–2263.

Beard, H.A., Hauser, J.R., Walko, M., George, R.M., Wilson, A.J. & Bon, R.S. (2019) Photocatalytic Proximity Labelling of MCL-1 by a BH3 Ligand, Commun. Chem., 2133, doi:10.1038/s42004-019-0235-z

Bunce, S.J., Wang, Y., Stewart, K.L., Ashcroft, A.E., Radford, S.E., Hall, C.K., Wilson, A.J (2019) Molecular Insights into the surface catalyzed secondary nucleation of Amyloid-β40 (Aβ40) by the peptide fragment Aβ16-22, Sci. Adv., 5, 6, eaav8216.

Wang, Y., Bunce, S., Radford, S.E., Wilson, A.J., Auer, S., Hall, C.K. (2019) Thermodynamic Phase Diagram of Amyloid-β (16-22) Peptide, Proc. Natl. Acad. Sci. USA, 116, 6, 2091-2096.

Hegedus, Z., Grison, C. M.,  Miles, J.A., Rodriguez-Marin, S., Warriner, S.L., Webb, M.E., Wilson, A.J. (2019) A Catalytic Protein–Proteomimetic Complex: Using Aromatic Oligoamide Foldamers as Activators of RNase S, Chem. Sci., 10, 3956-3962.

Bakail, M., Rodriguez-Marin, S., Hegedüs, Z., Perrin, M.E., Ochsenbein, F., Wilson, A.J. (2019) Recognition of ASF1 Using Hydrocarbon Constrained Peptides, ChemBioChem, 20, 7, 891-895.

Dos Santos Rodrigues, F.H.,  Firczuk, H., Breeze, A.L., Cameron, A.D., Walko, M.,  Wilson, A.J.,  Zanchin, N.I.T., McCarthy, J.E.G. (2019) The Leishmania PABP1–eIF4E4 interface: a novel 5′–3′ interaction architecture for trans-spliced mRNAs. Nucleic Acids Res., 47, 3, 1493-1504.

Horne, M., Walko, A. N., Calabrese, M. A., Levenstein, D. J., Brockwell, N., Kapur, A. J. Wilson, Radford, S.E. (2018) Rapid Mapping of Protein Interactions Using Tag-Transfer Photocrosslinkers. Angew. Chemie. Int. Ed., 57, 51, 16688–16692.

Fletcher, J.M., Horner, K.A., Bartlett, G.J., Rhys, G.G., Wilson, A.J., Woolfson, D.N. (2018) De novo coiled-coil peptides as scaffolds for disrupting protein–protein interactions. Chem. Sci., 9, 7656-7665.

Hewitt, S.H. & Wilson, A.J. (2018) Generation of Dynamic Combinatorial Libraries Using Hydrazone Functionalized Surface Mimetics. Eur. J. Org. Chem, 1872-1879.

Hewitt, S.H. & Wilson, A.J. (2017) Protein Sensing and Discrimination Using High Functionalised Ruthenium (II) tris(Bipyridyl) Protein Surface Mimetics in an Array Format. Chem. Commun. 53, 12278-12281.

Previously papers from the Investigators on this programme can be found here, and key papers in the field are here.